100325-51-7
100325-51-7 structure
- Name: CP-67015
- Chemical Name: 1-ethyl-6,8-difluoro-4-oxo-7-pyridin-4-ylquinoline-3-carboxylic acid
- CAS Number: 100325-51-7
- Molecular Formula: C17H12F2N2O3
- Molecular Weight: 330.28600
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
- Create Date: 2018-06-12 10:06:14
- Modify Date: 2024-01-15 17:14:51
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CP-67015, a nalidixic acid analog, is a potent topoisomerase II inhibitor. CP-67015 is a positive direct-acting mutagen in mammalian cells with both gene and chromosomal level effects[1].
| Name | 1-ethyl-6,8-difluoro-4-oxo-7-pyridin-4-ylquinoline-3-carboxylic acid |
|---|---|
| Synonyms |
3-Quinolinecarboxylic acid,1,4-dihydro-6,8-difluoro-1-ethyl-4-oxo-7-(4-pyridinyl)
3-Quinolinecarboxylicacid,1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(4-pyridinyl) CP-67,015 |
| Description | CP-67015, a nalidixic acid analog, is a potent topoisomerase II inhibitor. CP-67015 is a positive direct-acting mutagen in mammalian cells with both gene and chromosomal level effects[1]. |
|---|---|
| Related Catalog | |
| Target |
Topoisomerase II |
| In Vitro | CP-67015 (10-100 μg/mL; 12-36 h) produces a drastic increase in chromosome damage in human lymphocytes and in CHO cells[1]. CP-67015 inhibits supercoiling activity of prokaryotic DNA gyrase, with 100% inhibition at the concentration of 4.0 μg/mL[1]. |
| In Vivo | CP-67015 (a single dose 1000 mg/kg or 500 mg/kg/day for 5 days; i.p.) induces chromosome damage in male CD-1 mice in mouse bone marrow cells[1]. |
| References |
| Density | 1.424g/cm3 |
|---|---|
| Boiling Point | 496.7ºC at 760 mmHg |
| Molecular Formula | C17H12F2N2O3 |
| Molecular Weight | 330.28600 |
| Flash Point | 254.2ºC |
| Exact Mass | 330.08200 |
| PSA | 72.19000 |
| LogP | 3.05980 |
| Vapour Pressure | 1.11E-10mmHg at 25°C |
| Index of Refraction | 1.604 |
| WGK Germany | 3 |
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