508-44-1

508-44-1 structure

Name: Anemonine
Chemical Name: 1,7-Dioxadispiro[4.0.4.2]dodeca-3,9-diene-2,8-dione
CAS Number: 508-44-1
Molecular Formula: C₁₀H₈O₄
Molecular Weight: 192.17
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2018-09-04 12:22:12
Modify Date: 2025-08-25 05:52:24
Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases[1][2].

Name	1,7-Dioxadispiro[4.0.4.2]dodeca-3,9-diene-2,8-dione
Synonyms	1,7-Dinitro-naphthalin 1,7-dinitro-naphthalene 1,7-dioxa-dispiro[4.0.4.2]dodeca-3,9-diene-2,8-dione Naphthalene,1,7-dinitro 1,7-Dioxa-dispiro[4.0.4.2]dodeca-3,9-dien-2,8-dion Anemonine

Description	Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology Signaling Pathways >> TGF-beta/Smad >> PKC
References	[1]. Jiang L, et al. Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ. Chin Med. 2022 Mar 28;17(1):39. [2]. Lee TH, et al. Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor. J Ethnopharmacol. 2008 Mar 28;116(3):518-27.

CHEMICAL NAME :: 1,7-Dioxadispiro(4.0.4.2)dodeca-3,9-diene-2,8-dione, trans-

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946

Precursor 0
DownStream 3
502-50-1 110-15-6 144-62-7