415713-60-9

415713-60-9 structure

Name: RI-1
Chemical Name: 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
CAS Number: 415713-60-9
Molecular Formula: C₁₄H₁₁Cl₃N₂O₃
Molecular Weight: 361.608
Catalog: Signaling Pathways Cell Cycle/DNA Damage RAD51
Create Date: 2018-12-20 10:54:50
Modify Date: 2025-09-01 10:21:48
RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.IC50 Value: 5-30 μMTarget: RAD51in vitro: RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 μM range. RI-1 decreases the rejoining of γ-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation. in vivo:

Name	3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
Synonyms	1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)- 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione S8077,RAD51 inhibitor 1 3-Chloro-1-(3,4-dichloro-phenyl)-4-morpholin-4-yl-pyrrole-2,5-dione 3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione RI-1

Description	RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.IC50 Value: 5-30 μMTarget: RAD51in vitro: RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 μM range. RI-1 decreases the rejoining of γ-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation. in vivo:
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> RAD51 Research Areas >> Cancer
References	[1]. dke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 2012 May 9.

RIDADR	NONH for all modes of transport

110-91-8

65833-22-9

415713-60-9

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 22 p. 6560 - 6564

Precursor 2
110-91-8 65833-22-9
DownStream 0