192203-60-4

192203-60-4 structure

Name: Carboxypeptidase G2 (CPG2) Inhibitor
Chemical Name: (2S)-2-[(4-methoxyphenyl)sulfanylcarbonylamino]pentanedioic acid
CAS Number: 192203-60-4
Molecular Formula: C₁₃H₁₅NO₆S
Molecular Weight: 313.32600
Catalog: Biochemical Amino acids and their derivatives Glutamic acid derivative
Create Date: 2018-12-09 18:26:09
Modify Date: 2024-01-08 21:07:01
Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.

Name	(2S)-2-[(4-methoxyphenyl)sulfanylcarbonylamino]pentanedioic acid
Synonyms	CS-0824 Carboxypeptidase G2 (CPG2) Inhibitor L-Glutamic acid,N-[[(4-methoxyphenyl)thio]carbonyl] Carboxypeptidase G2 (CPG2) Inhibitor\|\|L-Glutamic acid,N-[[(4-methoxyphenyl)thio]carbonyl]

Description	Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Carboxypeptidase Research Areas >> Cancer
References	[1]. Khan, Tariq H.; Eno-Amooquaye, Ebun A.; Searle, Frances et al. Novel Inhibitors of Carboxypeptidase G2 (CPG2): Potential Use in Antibody-Directed Enzyme Prodrug Therapy. Journal of Medicinal Chemistry (1999), 42(6), 951-956. [2]. Friedlos F, Lehouritis P, Ogilvie L et al. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy. Clin Cancer Res. 2008 Jul 1;14(13):4259-66. [3]. Schepelmann S, Ogilvie LM, Hedley D et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 2007 May 15;67(10):4949-55. [4]. Schepelmann S, Hallenbeck P, Ogilvie LM et al. Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2. Cancer Res. 2005 Jun 15;65(12):5003-8.