- BioBioPha
- China
- Product Name: 5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol
- Price: ￥4250.0/5mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol
- Price: ￥5120.0/5mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
69120-06-5
69120-06-5 structure
- Name: 5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol
- Chemical Name: 5-(6-hydroxy-1-benzofuran-2-yl)-2-(3-methylbut-2-enyl)benzene-1,3-diol
- CAS Number: 69120-06-5
- Molecular Formula: C19H18O4
- Molecular Weight: 310.344
- Catalog: Natural product Phenols
- Create Date: 2016-04-23 19:22:38
- Modify Date: 2024-01-07 19:25:20
-
Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells[1].
| Name | 5-(6-hydroxy-1-benzofuran-2-yl)-2-(3-methylbut-2-enyl)benzene-1,3-diol |
|---|---|
| Synonyms |
Moracin C
1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-buten-1-yl)- 5-(6-Hydroxy-1-benzofuran-2-yl)-2-(3-methyl-2-buten-1-yl)-1,3-benzenediol 1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-butenyl)- 5-(6-Hydroxy-benzofuran-2-yl)-2-(3-methyl-but-2-enyl)-benzene-1,3-diol |
| Description | Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells[1]. |
|---|---|
| Related Catalog | |
| Target |
COX-2 |
| In Vitro | Moracin C (1-50 μM，24 小时) 抑制 RAW264.7 细胞释放 LPS 激活的活性氧 (ROS) 和一氧化氮 (NO)[1]。 Moracin C (1-50 μM, 2 h) 抑制 RAW264.7 细胞中 iNOS 和 COX-2 的 mRNA 和蛋白表达[1]。 Moracin C (1-50 μM，2 小时) 抑制 LPS 激活的 RAW 264.7 细胞中促炎细胞因子 (IL-1β、IL-6 和 TNF-α) 的产生[1]。 Moracin C (1-50 μM，2 小时) 抑制 LPS 激活的 RAW 264.7 细胞中 p38、ERK 和 JNK 的磷酸化[1]。 RT-PCR[1] Cell Line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM Incubation Time: 2 h Result: Inhibited LPS-induced mRNA expression of iNOS and COX-2. Western Blot Analysis[1] Cell Line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM Incubation Time: 2 h Result: Inhibited LPS-induced TLR4 expression and NF-κB activation. Reduced phosphorylated p38, ERK and JNK levels. |
| In Vivo | Moracin C (100 mg/kg，灌胃，小鼠) 在肠道内吸收迅速、吸收良好，在胃肠道、肝脏、肾脏和肺部分布较广[2]。 Animal Model: Mice (PK Assay)[2] Dosage: 100 mg/kg Administration: Oral gavage Result: Pharmacokinetic profile of Moracin C. Parameters Terminal half-life (min) Cmax (μg/mL) Tmax (min) CLR (mL/min/kg) 100 mg/kg 256 1.79 15 0.032 |
| References |
[2]. You BH, et al. Pharmacokinetic Properties of Moracin C in Mice. Planta Med. 2021 Jul;87(8):642-651. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 439.4±35.0 °C at 760 mmHg |
| Molecular Formula | C19H18O4 |
| Molecular Weight | 310.344 |
| Flash Point | 219.6±25.9 °C |
| Exact Mass | 310.120514 |
| PSA | 73.83000 |
| LogP | 4.46 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.664 |
| Hazard Codes | Xi |
|---|
| Precursor 4 | |
|---|---|
| DownStream 0 | |
