Name | 4-chloromethyl-2-methylthiazole hydrochloride |
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Synonyms |
BUTTPARK 452-17
4-(Chloromethyl)-2-methyl-1,3-thiazoleHCl (4-(Chloromethyl)-2-methythiazole Hydrochloride) 2-methyl-4-chloromethyl-1,3-thiazole hydrochloride 4-(chloromethyl)-2-methylthiazole monohydrochloride 4-ChloroMethyl-2-Methylthiazole hydrochloride 1GR 2-methyl-4-chloromethylthiazole hydrochloride 4-(CHLOROMETHYL)-2-METHYL-1,3-THIAZOLE HYDROCHLORIDE 2-methyl-4-(chloromethyl)thiazole monohydrochloride 4-(Chloromethyl)-2-methylthiazole hydrochloride 4-(chloromethyl)-2-methylthiazole HCl Thiazole,4-(chloroMethyl)-2-Methyl-,hydrochloride MFCD00067725 |
Boiling Point | 217.5ºC at 760 mmHg |
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Melting Point | 161-163 °C |
Molecular Formula | C5H7Cl2NS |
Molecular Weight | 184.08700 |
Flash Point | 85.3ºC |
Exact Mass | 182.96800 |
PSA | 41.13000 |
LogP | 2.99230 |
Storage condition | -20°C Freezer |
Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 34 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Causes burns. Potential Health Effects Eye: Causes eye burns. Skin: Causes skin burns. Ingestion: Causes gastrointestinal tract burns. Inhalation: Causes chemical burns to the respiratory tract. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Do not induce vomiting. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use foam, dry chemical, or carbon dioxide. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 77470-53-2: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: off-white - grey Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 167 - 170 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Not available. Solubility in water: Specific Gravity/Density: Molecular Formula: C5H7Cl2NS Molecular Weight: 184 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents, bases. Hazardous Decomposition Products: Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 77470-53-2 unlisted. LD50/LC50: Not available. Carcinogenicity: 4-(Chloromethyl)-2-methyl-1,3-thiazole hydrochloride - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.* Hazard Class: 8 UN Number: 3261 Packing Group: III IMO Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. Hazard Class: 8 UN Number: 3261 Packing Group: III RID/ADR Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. Hazard Class: 8 UN Number: 3261 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: C Risk Phrases: R 34 Causes burns. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 77470-53-2: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 77470-53-2 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 77470-53-2 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
Hazard Codes | C: Corrosive; |
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Risk Phrases | R34 |
Safety Phrases | S45-S36/37/39-S26 |
RIDADR | 3261 |
~95% 77470-53-2 |
Literature: Merck Sharp and Dohme Limited; DIRAT, Olivier; ELLIOTT, Jason, Matthew Patent: WO2007/3965 A1, 2007 ; Location in patent: Page/Page column 37 ; WO 2007/003965 A1 |
~86% 77470-53-2 |
Literature: Cohen, Anita; Crozet, Maxime D.; Rathelot, Pascal; Azas, Nadine; Vanelle, Patrice Molecules, 2013 , vol. 18, # 1 p. 97 - 113 |
~% 77470-53-2 |
Literature: Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617 |
Precursor 2 | |
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DownStream 7 | |