20601-85-8

20601-85-8 structure

Name: Tetrahydromagnolol
Chemical Name: 2-(2-hydroxy-5-propylphenyl)-4-propylphenol
CAS Number: 20601-85-8
Molecular Formula: C₁₈H₂₂O₂
Molecular Weight: 270.366
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2018-07-24 10:32:53
Modify Date: 2024-01-07 09:21:37
Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1].

Name	2-(2-hydroxy-5-propylphenyl)-4-propylphenol
Synonyms	MLO [1,1'-Biphenyl]-2,2'-diol, 5,5'-dipropyl- 2,2'-dihydroxy-5,5'-dipropylbiphenyl 5,5'-propyl-2,2'-dihydroxy-1,1'-biphenyl 5,5'-Dipropyl-2,2'-biphenyldiol 5.5'-Dipropyl-biphenyl-2.2'-diol 5,5'-dipropylbiphenyl-2,2'-diol tetrahydro-magnolol 6,6'-Dihydroxy-3,3'-dipropyl-biphenyl

Description	Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> GPR55 Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	CB2:170 nM (EC50) CB2:416 nM (Ki) CB1:9010 nM (EC50) CB1:2260 nM (Ki) GPR55 receptor
References	[1]. Alexander Fuchs, et al. The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists. PLoS One. 2013 Oct 30;8(10):e77739.

HS Code	2907299090

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%