DC Chemicals Limited
China
Product Name: NPS2390
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

226878-01-9

226878-01-9 structure

226878-01-9 structure

Name: NPS 2390
Chemical Name: N-(1-adamantyl)quinoxaline-2-carboxamide
CAS Number: 226878-01-9
Molecular Formula: C₁₉H₂₁N₃O
Molecular Weight: 307.389
Create Date: 2016-04-12 02:14:27
Modify Date: 2024-01-06 10:26:29
NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5[1]. NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor[2][3].

Name	N-(1-adamantyl)quinoxaline-2-carboxamide
Synonyms	N-(tricyclo[3.3.1.1]dec-1-yl)quinoxaline-2-carboxamide 2-quinoxaline-carboxamide-N-adamantan-1-yl N-(Adamantan-1-yl)-2-quinoxalinecarboxamide 2-Quinoxalinecarboxamide, N-tricyclo[3.3.1.1]dec-1-yl- Quinoxaline-2-carboxylic acid adamantan-1-ylamide NPS 2390

Description	NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5[1]. NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor[2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> CaSR
Target	mGluR1 mGluR5
References	[1]. Vanejevs M, et al. Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47. [2]. Peng X, et al. NPS2390, a Selective Calcium-sensing Receptor Antagonist Controls the Phenotypic Modulation of Hypoxic Human Pulmonary Arterial Smooth Muscle Cells by Regulating Autophagy. J Transl Int Med. 2019 Jul 11;7(2):59-68. [3]. Xue Z, et al. Calcium-sensing receptor antagonist NPS2390 attenuates neuronal apoptosis though intrinsic pathway following traumatic brain injury in rats. Biochem Biophys Res Commun. 2017 Apr 29;486(2):589-594.

Density	1.3±0.1 g/cm3
Boiling Point	542.4±30.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₁N₃O
Molecular Weight	307.389
Flash Point	281.9±24.6 °C
Exact Mass	307.168457
PSA	54.88000
LogP	3.65
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.658

Precursor 2
54745-92-5 768-94-5
DownStream 0