50298-90-3

50298-90-3 structure

Name: Cucurbitacin IIB
Chemical Name: Cucurbitacin IIB
CAS Number: 50298-90-3
Molecular Formula: C₃₀H₄₈O₇
Molecular Weight: 520.698
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-08-05 20:20:23
Modify Date: 2025-08-27 08:10:54
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α[1].

Name	Cucurbitacin IIB
Synonyms	19-Norlanost-5-ene-11,22-dione, 2,3,16,20,25-pentahydroxy-9-methyl-, (2β,3α,9β,10α,16α)- (1S,2S,4R,9β,16α)-1,2,16,20,25-Pentahydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-ene-11,22-dione 25-deacetyl hemslecin A 22,23-dihydrocucurbitacin F Estr-5-en-11-one, 17-[(1R)-1,5-dihydroxy-1,5-dimethyl-2-oxohexyl]-2,3,16-trihydroxy-4,4,9,14-tetramethyl-, (2β,3α,9β,10α,16α,17β)- 23,24-Dihydrocucurbitacin F dihydrocucurbitacin F CucurbitacinⅡb Cucurbitacin Ⅱb

Description	Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology
References	[1]. Wang Y, et al. Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. PLoS One. 2014 Feb 25;9(2):e89751.

5939-57-1

50298-90-3

Precursor 1
5939-57-1
DownStream 0