51-40-1
51-40-1 structure
- Name: Noradrenaline tartrate
- Chemical Name: l-Noradrenaline tartrate
- CAS Number: 51-40-1
- Molecular Formula: C12H17NO9
- Molecular Weight: 319.265
- Catalog: API Circulatory system medication Anti-shock vasoactive drug
- Create Date: 2018-09-30 22:02:23
- Modify Date: 2024-01-04 11:36:26
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Norepinephrine tartrate (Levarterenol tartrate), a naturally occurring chemical in the body that acts as both a stress hormone and neurotransmitter, is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.
| Name | l-Noradrenaline tartrate |
|---|---|
| Synonyms |
Norepinephrine Bitartrate
l-noradrenalinetartrate noradrenaline bitartrate Levarterenolbitartrate MFCD00036384 4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxysuccinate (1:1) Leverterenol bitartrate noradrenalinetartrate 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol 2,3-dihydroxysuccinate (1:1) 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, 2,3-dihydroxybutanedioate (1:1) (salt) L-ARTERENOL BITARTRATE Noradrenalineacidtartrate 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxybutanedioate (1:1) NORADRENALINE EINECS 200-095-0 Levoarterenol bitartrate |
| Description | Norepinephrine tartrate (Levarterenol tartrate), a naturally occurring chemical in the body that acts as both a stress hormone and neurotransmitter, is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. |
|---|---|
| Related Catalog | |
| Target |
EC50: 5.37 μM (β1-selective adrenergic receptor)[1]. |
| In Vitro | Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine (NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment[2]. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2]. RT-PCR[2] Cell Line: Subcutaneous preadipocytes Adipocytes. Concentration: 10 μM. Incubation Time: 6 hours. Result: AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA) |
| References |
| Boiling Point | 442.6ºC at 760 mmHg |
|---|---|
| Molecular Formula | C12H17NO9 |
| Molecular Weight | 319.265 |
| Flash Point | 221.5ºC |
| Exact Mass | 319.090332 |
| PSA | 201.77000 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Hazard Codes | T+ |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | UN 3249 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2922210000 |
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |