CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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XU5250000
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CHEMICAL NAME :
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o-Toluidine, 4-chloro-, hydrochloride
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CAS REGISTRY NUMBER :
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3165-93-3
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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21
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MOLECULAR FORMULA :
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C7-H8-Cl-N.Cl-H
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MOLECULAR WEIGHT :
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178.07
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WISWESSER LINE NOTATION :
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ZR DG B1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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560 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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680 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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49 gm/kg/78W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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104 gm/kg/99W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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108 gm/kg/78W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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216 gm/kg/78W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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97 gm/kg/78W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
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TYPE OF TEST :
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Specific locus test
MUTATION DATA
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TYPE OF TEST :
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Sister chromatid exchange
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TEST SYSTEM :
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Rodent - hamster Ovary
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DOSE/DURATION :
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50 mg/L
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REFERENCE :
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EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,123,1990 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,277,1978 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,277,1978 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,123,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1279 No. of Facilities: 45 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 682 (estimated) No. of Female Employees: 425 (estimated)
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