Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: mannomustine
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Purity: 98.0%
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576-68-1

576-68-1 structure

Name: mannomustine
Chemical Name: (2R,3R,4R,5R)-1,6-bis(2-chloroethylamino)hexane-2,3,4,5-tetrol
CAS Number: 576-68-1
Molecular Formula: C₁₀H₂₂Cl₂N₂O₄
Molecular Weight: 305.19900
Catalog: API Antineoplastic agents Alkylating agent
Create Date: 2018-08-02 16:46:59
Modify Date: 2025-08-26 14:42:10

Name	(2R,3R,4R,5R)-1,6-bis(2-chloroethylamino)hexane-2,3,4,5-tetrol
Synonyms	Mannit-lost [German] Mannomustin Mannitol nitrogen mustard Manomustina [INN-Spanish] Mannomustine [INN:BAN:DCF] Mannit-mustard [German] Mannit-Lost Mannomustinum [INN-Latin] 1,6-Bis-<(2-chlorethyl)-amino>-1,6-dideoxy-D-mannitol 1,6-Bis-(2-chlor-aethylamino)-1,6-didesoxy-D-mannit BCM (cytostatic) mannomustine 1,6-bis-(2-chloro-ethylamino)-1,6-dideoxy-D-mannitol 1,6-Bis-<2-chlor-ethylamino>-1,6-didesoxy-D-mannit

Density	1.353g/cm3
Boiling Point	541.9ºC at 760 mmHg
Melting Point	278°C (rough estimate)
Molecular Formula	C₁₀H₂₂Cl₂N₂O₄
Molecular Weight	305.19900
Flash Point	281.5ºC
Exact Mass	304.09600
PSA	104.98000
Index of Refraction	1.544

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OP2100000

CHEMICAL NAME :: Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-, D-,

CAS REGISTRY NUMBER :: 576-68-1

LAST UPDATED :: 199707

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C10-H22-Cl2-N2-O4

MOLECULAR WEIGHT :: 305.24

WISWESSER LINE NOTATION :: G2M1YQYQYQYQ1M2G -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Tumorigenic - protects against induction of experimental tumors

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Blood - leukopenia

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Cells - not otherwise specified

DOSE/DURATION :: 2900 nmol/L

REFERENCE :: SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 18,210,1982

16658-08-5

576-68-1

Literature: Vargha et al. Journal of the Chemical Society, 1957 , p. 805,809

108991-70-4

576-68-1

Literature: Vargha et al. Journal of the Chemical Society, 1957 , p. 805,809

7465-84-1

576-68-1

Literature: Vargha et al. Journal of the Chemical Society, 1957 , p. 805,809

Precursor 3
16658-08-5 108991-70-4 7465-84-1
DownStream 0

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