2424-92-2

2424-92-2 structure

Name: Icosanedioic acid
Chemical Name: eicosanedioic acid
CAS Number: 2424-92-2
Molecular Formula: C₂₀H₃₈O₄
Molecular Weight: 342.513
Catalog: Organic raw materials Carboxylic compounds and derivatives Acyclic carboxylic acid
Create Date: 2018-05-09 08:00:00
Modify Date: 2025-08-25 11:00:17
Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

Name	eicosanedioic acid
Synonyms	eicosadioic acid Icosanedioic acid 1,18-Octadecanedicarboxylic acid eicosa-1,20-dioic acid eicosane diacid 1,20-icosanedioic acid Eicossandioic acid eicosandioic acid Eicosanedioic acid MFCD00059627 octadecane-1,18-dicarboxylic acid

Description	Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Safety Phrases	S22-S24/25
HS Code	2917190090

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%