12676-15-2
12676-15-2 structure
- Name: angiotensin iv
- Chemical Name: angiotensin iv
- CAS Number: 12676-15-2
- Molecular Formula: C40H54N8O8
- Molecular Weight: 774.90600
- Catalog: Peptides
- Create Date: 2016-06-22 00:13:44
- Modify Date: 2024-01-07 21:34:10
-
Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.
| Name | angiotensin iv |
|---|---|
| Synonyms |
Ang IV Angiotensin II (3-8)
angiotensin III,1-desarginine Ang IV,Angiotensin II (3-8) (2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid Angiotensin IV trifluoroacetate salt Angiotensin II (3-8), human |
| Description | Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor. |
|---|---|
| Related Catalog | |
| Target |
Angiotensin AT1 receptor[1] |
| In Vivo | Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances[1]. |
| Animal Admin | Rats[1] Male Long Evans rats (350-450 g) (n=7) are given increasing bolus doses of AII (1.25, 12.5 and 125 pmol/kg) or human Angiotensin II (3-8) (0.125, 1.25 and 12.5 nmol/kg) in random order, in the morning or afternoon of the same experimental day. Injections are separated by at least 20 min to allow variables to return to baseline[1]. |
| References |
| Molecular Formula | C40H54N8O8 |
|---|---|
| Molecular Weight | 774.90600 |
| Exact Mass | 774.40600 |
| PSA | 248.94000 |
| LogP | 3.38920 |
| WGK Germany | 3 |
|---|