145667-75-0
145667-75-0 structure
- Name: Latanoprost lactone diol
- Chemical Name: (3aR,4R,5R,6aS)-5-hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
- CAS Number: 145667-75-0
- Molecular Formula: C18H24O4
- Molecular Weight: 304.381
- Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
- Create Date: 2018-08-19 07:54:16
- Modify Date: 2025-08-21 14:10:26
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Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost. Latanoprost is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP)[1].
| Name | (3aR,4R,5R,6aS)-5-hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one |
|---|---|
| Synonyms |
(3aR,4R,5R,6aS)-5-Hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]hexahydro-2H-cyclopenta[b]furan-2-one
LatanoprostLactoneDiol 2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]-, (3aR,4R,5R,6aS)- |
| Description | Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost. Latanoprost is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP)[1]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 523.0±35.0 °C at 760 mmHg |
| Melting Point | 69-71ºC |
| Molecular Formula | C18H24O4 |
| Molecular Weight | 304.381 |
| Flash Point | 190.3±19.4 °C |
| Exact Mass | 304.167450 |
| PSA | 66.76000 |
| LogP | 0.60 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.568 |
|
~79%
145667-75-0 |
| Literature: Chirogate International Inc. Patent: EP1810967 A1, 2007 ; Location in patent: Page/Page column 20-21 ; |
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~85%
145667-75-0 |
| Literature: Resul, Bahram; Stjernschantz, Johan; No, Kiyo; Liljebris, Charlotta; Selen, Goeran; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 2 p. 243 - 248 |
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145667-75-0 |
| Literature: EP1886992 A1, ; Page/Page column 9 ; |
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145667-75-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 36, # 2 p. 243 - 248 |
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145667-75-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 36, # 2 p. 243 - 248 |
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145667-75-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 36, # 2 p. 243 - 248 |
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145667-75-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 36, # 2 p. 243 - 248 |
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145667-75-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 36, # 2 p. 243 - 248 |
