402473-54-5
402473-54-5 structure
- Name: ONO-AE3-208
- Chemical Name: 4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid
- CAS Number: 402473-54-5
- Molecular Formula: C24H21FN2O3
- Molecular Weight: 404.434
- Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
- Create Date: 2018-12-20 16:08:18
- Modify Date: 2025-08-28 22:22:44
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ONO-AE3-208 is an EP4 antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer.
| Name | 4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid |
|---|---|
| Synonyms |
4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid
ONO AE3 208 4-[4-cyano-2-[2-(4-fluoro-1-naphthyl)propanoylamino]phenyl]butanoic acid 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid ONO-AE3-208||ONO AE3 208 4-(4-Cyano-2-{[2-(4-fluoro-1-naphthyl)propanoyl]amino}phenyl)butanoic acid Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]- ONO-AE3-208 |
| Description | ONO-AE3-208 is an EP4 antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer. |
|---|---|
| Related Catalog | |
| Target |
EP4 |
| In Vitro | ONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation[1]. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208[2]. |
| In Vivo | ONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice[1]. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls[3]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 662.4±55.0 °C at 760 mmHg |
| Molecular Formula | C24H21FN2O3 |
| Molecular Weight | 404.434 |
| Flash Point | 354.4±31.5 °C |
| Exact Mass | 404.153625 |
| PSA | 90.19000 |
| LogP | 4.56 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.637 |
| Storage condition | 2-8℃ |