152633-54-0

152633-54-0 structure
152633-54-0 structure
  • Name: Win-62005
  • Chemical Name: 5-methyl-6-pyridin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one
  • CAS Number: 152633-54-0
  • Molecular Formula: C12H10N4O
  • Molecular Weight: 226.23400
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
  • Create Date: 2016-04-19 12:20:02
  • Modify Date: 2024-01-31 23:03:08
  • Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.

Name 5-methyl-6-pyridin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one
Synonyms 2H-Imidazo(4,5-b)pyridin-2-one,1,3-dihydro-5-methyl-6-(4-pyridinyl)
5-Methyl-6-(4-pyridinyl)-2H-imidazo(4,5-b)pyridin-2-one
Win-62005
Description Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.
Related Catalog
Target

Ki: 25 nM (PDE III), 25 nM (PDE III)[1]

In Vitro Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with Ki values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes[1].
In Vivo After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h[1].
References

[1]. Dundore RL, et al. Species-dependent pharmacodynamic effects of the selective low Km cyclic AMP phosphodiesterase III inhibitors WIN 58993 and WIN 62005. J Cardiovasc Pharmacol. 1995 Jan;25(1):14-21.

Density 1.292g/cm3
Boiling Point 291.8ºC at 760 mmHg
Molecular Formula C12H10N4O
Molecular Weight 226.23400
Flash Point 130.3ºC
Exact Mass 226.08500
PSA 74.69000
LogP 2.03390
Vapour Pressure 0.00191mmHg at 25°C
Index of Refraction 1.621
Storage condition 2-8℃