163253-37-0
163253-37-0 structure
- Name: Sitafloxacin
- Chemical Name: 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid,hydrate
- CAS Number: 163253-37-0
- Molecular Formula: C19H18ClF2N3O3
- Molecular Weight: 409.81400
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2017-01-01 13:44:38
- Modify Date: 2025-08-25 09:14:55
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Sitafloxacin (DU6859a) monohydrate is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin monohydrate shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin monohydrate can be used for the research of respiratory tract infection and urinary tract infection[1][2].
| Name | 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid,hydrate |
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| Synonyms |
Sitafloxacin hydrate
7-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid hydrate (1:1) Spifloxacin hydrate UNII-45IP57B62B Gracevit 3-Quinolinecarboxylic acid, 7-[(7S)-7-amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-, hydrate (1:1) Sitafloxacin |
| Description | Sitafloxacin (DU6859a) monohydrate is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin monohydrate shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin monohydrate can be used for the research of respiratory tract infection and urinary tract infection[1][2]. |
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| Related Catalog | |
| In Vitro | Sitafloxacin (DU6859a) monohydrate shows antibacterial activities with MIC of 0.03, 0.12, 0.06 mg/L for wild-type ATCC 49619, gyrA mutant SP39, parC mutant 1026523 streptococcus pneumoniae stran, respectively[1]. Sitafloxacin (DU6859a) monohydrate shows antibacterial activities for quinolone-susceptible strains of streptococcus pneumoniae with MIC of 0.03, 0.03 mg/L for EG 00093 and EG 00218 strain, respectively[1]. Sitafloxacin (DU6859a) monohydrate shows inhibition for DNA gyrase and topoisomerase IV (TopoIV) with >IC50s of 4.38, 3.12 mg/L, respectively[1]. |
| In Vivo | Sitafloxacin (DU6859a; 12.5-100 mg/kg; i.g.; daily for 4 weeks; BALB/c female mice) monohydrate has antibacterial activity. M. ulcerans cells could be isolated from the inoculated footpads and there was no evidence of footpad swelling[2]. Animal Model: BALB/c female mice[2] Dosage: 12.5, 25, 50 and 100 mg/kg Administration: Oral gavage; daily, for 4 weeks Result: Inhibits the growth of Mycobacterium ulcerans and the M. ulcerans cells. |
| References |
| Molecular Formula | C19H18ClF2N3O3 |
|---|---|
| Molecular Weight | 409.81400 |
| Exact Mass | 409.10000 |
| PSA | 88.56000 |
| LogP | 3.46790 |