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1754-62-7

1754-62-7 structure
1754-62-7 structure
Name methyl cinnamate
Synonyms MFCD00008458
Methyl trans-cinnamate
Description Methyl (E)-cinnamate (EMC), a phytochemical constituent isolated from Alpinia katsumadai Hayata, is a natural flavor compound with anti-inflammatory properties. Methyl (E)-cinnamate is widely used in the food and commodity industry[1].
Related Catalog
In Vitro Methyl (E)-cinnamate (0~30 μM; 24 hours; MC3T3-E1 cells) significantly increases the cleaved forms of poly (ADP-ribose) polymerase (PARP) and caspase-3, while it decreases the expression levels of Survivin and Bcl-2, and significantly increases TUNEL-positive and DAPI-stained cells[1]. Methyl (E)-cinnamate (0~30 μM;7 days; MC3T3-E1 cells) suppresses the osteoblast differentiation[1]. Methyl (E)-cinnamate (1~100 μM; 24 and 48 hours; MC3T3-E1 cells) decreases cell survival and induces morphological changes. EMC decreases MAPKs signaling and cell migration[1]. Western Blot Analysis[1] Cell Line: MC3T3-E1 cells Concentration: 0~30 μM Incubation Time: 24 hours Result: Significantly increased the cleaved forms of poly (ADP-ribose) polymerase (PARP) and caspase-3, while it decreased the expression levels of Survivin and Bcl-2. Apoptosis Analysis[1] Cell Line: MC3T3-E1 cells Concentration: 0~30 μM Incubation Time: 24 hours Result: Significantly increased TUNEL-positive and DAPI-stained cells. Cell Differentiation Assay[1] Cell Line: MC3T3-E1 cells Concentration: 0~30 μM Incubation Time: 7 days Result: Suppressed the osteoblast differentiation.
References

[1]. Park KR, et al. A Phytochemical Constituent, (E)-Methyl-Cinnamate Isolated from Alpinia katsumadai Hayata Suppresses Cell Survival, Migration, and Differentiation in Pre-Osteoblasts. Int J Mol Sci. 2020;21(10):3700. Published 2020 May 24.
Density 1.078 g/cm3
Boiling Point 261.9ºC at 760 mmHg
Melting Point 34-38ºC
Molecular Formula C10H10O2
Molecular Weight 162.18500
Flash Point 141.3ºC
Exact Mass 162.06800
PSA 26.30000
LogP 1.87280
Vapour Pressure 0.0112mmHg at 25°C
Index of Refraction 1.558
Storage condition 2-8°C
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS GE0190000
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title: CAS No. 1754-62-7 | Chemsrc address: https://www.chemsrc.com/en/baike/907098.html

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