DC Chemicals Limited
China
Product Name: (-)-JQ-1
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

1268524-71-5

1268524-71-5 structure

1268524-71-5 structure

Name: (-)-JQ-1
Chemical Name: ()-jq1
CAS Number: 1268524-71-5
Molecular Formula: C₂₃H₂₅ClN₄O₂S
Molecular Weight: 456.988
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2016-04-12 17:08:59
Modify Date: 2024-01-21 15:03:00
(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.

Name	()-jq1
Synonyms	6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)- 2-Methyl-2-propanyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate (R)-(-)-JQ1 Enantiomer

Description	(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.
Related Catalog	Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain Research Areas >> Cancer
Target	BET bromodomain[1]
In Vitro	(−)-JQ1 shows no significant interaction with any bromodomain. Besides, (−)-JQ1 enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC)[1].
References	[1]. Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73. [2]. Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163.

Density	1.3±0.1 g/cm3
Boiling Point	610.4±65.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₅ClN₄O₂S
Molecular Weight	456.988
Flash Point	322.9±34.3 °C
Exact Mass	456.138672
PSA	97.61000
LogP	4.49
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.657
Storage condition	-20°C

RIDADR	NONH for all modes of transport