777075-44-2

777075-44-2 structure

Name: cis-ACCP
Chemical Name: cis-ACCP
CAS Number: 777075-44-2
Molecular Formula: C₇H₁₅N₂O₄P
Molecular Weight: 222.179
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2017-05-25 01:13:58
Modify Date: 2025-08-25 08:30:03
cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases[1].

Name	cis-ACCP
Synonyms	Phosphonic acid, [[[(1R,2S)-2-aminocyclohexyl]amino]carbonyl]-

Description	cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP-2:4 μM (IC50) MMP-9:20 μM (IC50)
In Vitro	cis-ACCP 可以抑制 MMP-2 和 MMP-9，IC50 值分别为 4 μM 和 20 μM[1]。
In Vivo	cis-ACCP（i.p.；50、250、500 mg/kg；每天一次，持续两周）没有显示出毒性作用并减少小鼠转移形成[1]。 cis-ACCP（口服，i.v.，i.p.；50、150 mg/kg）仅分布在细胞外液中[1]。 Animal Model: C57BL mice[1] Dosage: 50, 250, 500 mg/kg; 12.5 to 50 mg/kg Administration: Oral, intraperitoneal, daily for two weeks; daily, 21 days Result: Showed no toxic effects and showed 50-85% inhibition of metastasis formation, depending on the dose. Animal Model: Rats[1] Dosage: 50, 150 mg/kg Administration: Oral, intravenous, intraperitoneal Result: Showed 84% of the intravenously administered drug are excreted unchanged.
References	[1]. Hoffman, Amnon et al. Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor--synthesis and pharmacodynamic and pharmacokinetic analysis. Journal of medicinal chemistry vol. 51,5 (2008): 1406-14.

Density	1.4±0.1 g/cm3
Molecular Formula	C₇H₁₅N₂O₄P
Molecular Weight	222.179
Exact Mass	222.076950
PSA	122.46000
LogP	-2.04
Index of Refraction	1.544

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