Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
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Purity: 98.0%
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77453-01-1

77453-01-1 structure

Name: SKF 100398
Chemical Name: β-MERCAPTO-β,β-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
CAS Number: 77453-01-1
Molecular Formula: C₅₃H₇₇N₁₃O₁₁S₂
Molecular Weight: 1136.39000
Catalog: Signaling Pathways GPCR/G Protein Vasopressin Receptor
Create Date: 2018-12-22 21:57:38
Modify Date: 2025-08-27 09:56:57
SKF 100398 (d(CH2)5Tyr(Et)VAVP) is an arginine vasopressin (AVP) analogue, and acts as a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP[1].

Name	β-MERCAPTO-β,β-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
Synonyms	M.W. 1136.41 C53H77N13O11S2 type 1 arginine vasopressin antagonist (d(CH2)51,Tyr(Et)2,Val4,Arg8)-Vasopressin

Description	SKF 100398 (d(CH2)5Tyr(Et)VAVP) is an arginine vasopressin (AVP) analogue, and acts as a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor Research Areas >> Metabolic Disease
In Vivo	SKF 100398 is a specific antagonist of the hydrosmotic effect of exogenous and endogenous AVP[1]. SKF 100398 (8 μg/kg; i.v.) abolishes the antidiuretic effect of AVP[1]. Animal Model: Male Sprague-Dawley rats (250-300 g)[1] Dosage: 8 μg/kg Administration: Intravenous injection Result: Completely blocked the antidiuretic effect of exogenous AVP (4 ng/kg body wt i.v.).
References	[1]. S Ishikawa, et al. Further in vivo evidence for antagonist-to-antidiuretic action of arginine vasopressin. Am J Physiol. 1983 Nov;245(5 Pt 1):R713-9.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H332
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	20
Safety Phrases	36
RIDADR	NONH for all modes of transport

112453-06-2

77453-01-1

Literature: Manning, Maurice; Lammek, Bernard; Kolodziejczyk, Alexander M. Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 701 - 706