BioBioPha
China
Product Name: Euphorbia factor L3
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Euphorbia factor L3
Price: ￥2438.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 5,15-Diacetyl-3-benzoyllathyrol
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DIACETYL BENZOYL LATHYROL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

218916-52-0

218916-52-0 structure

218916-52-0 structure

Name: Euphorbia factor L3
Chemical Name: Diacetyl benzoyl lathyrol
CAS Number: 218916-52-0
Molecular Formula: C₃₁H₃₈O₇
Molecular Weight: 522.629
Catalog: Natural product Moss
Create Date: 2018-09-03 14:00:34
Modify Date: 2024-01-02 03:36:29
5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.

Name	Diacetyl benzoyl lathyrol
Synonyms	(1aR,2E,4aR,6S,7S,7aR,8R,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-9-methylene-4-oxo-1a,4,4a,5,6,7,7a,8,9,10,11,11a-dodecahydro-1H-cyclopenta[a]cyclopropa[f][11]annulen-7-yl benzoate 5,15-Diacetyl-3-benzoyllathyrol Euphorbia factor L3 Gongjinhyang seol whitening intensive cream 4H-Cyclopenta[a]cyclopropa[f]cycloundecen-4-one, 4a,8-bis(acetyloxy)-7-(benzoyloxy)-1,1a,4a,5,6,7,7a,8,9,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-9-methylene-, (1aR,2E,4aR,6S,7S,7aR,8R,11aS)-

Description	5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer
In Vitro	5,15-Diacetyl-3-benzoyllathyrol shows anticancer activity in vitro against lung cancer A549 cells and the IC50 values are 34.04±3.99 μM. Furthermore, 5,15-Diacetyl-3-benzoyllathyrol can induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c[1].
Cell Assay	Cells are harvested during logarithmic growth phase and seeded in 96-well plates at a density of 1.5×104 cells/mL of final volume 190 μL/well. After incubation of 24 h, 10 μL EFL3 solution of full range concentrations is added to 96-well plates. After 68 h treatment, 10 μL MTT of 10 mM is added to each well for 4 h of maintaining at 37°C. Then, the supernatant is removed and the crystals are dissolved with 100 μL anhydrous DMSO each well. Subsequently, cell viability is measured by Model 550 Microplate reader at 540 nm and 655 nm as reference filter. Experiments are carried out at least thrice. The 50% inhibitory concentration (IC50) is defined as the anticancer agent concentration causing 50% reduction in cell viability and calculated from the cytotoxicity curves. Cell survival is calculated with the following formula: survival (%)=(mean experimental absorbance/mean control absorbance) × 100%.
References	[1]. Zhang JY, et al. Structure identification of Euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway. Molecules. 2011 Apr 15;16(4):3222-31.

Density	1.2±0.1 g/cm3
Boiling Point	595.5±50.0 °C at 760 mmHg
Molecular Formula	C₃₁H₃₈O₇
Molecular Weight	522.629
Flash Point	249.0±30.2 °C
Exact Mass	522.261780
PSA	95.97000
LogP	7.25
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.557
Storage condition	-20℃