100940-65-6
100940-65-6 structure
- Name: Sandramycin
- Chemical Name: sandramycin
- CAS Number: 100940-65-6
- Molecular Formula: C60H76N12O16
- Molecular Weight: 1221.32000
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2017-06-01 04:26:08
- Modify Date: 2025-08-27 22:15:57
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Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity[1][2][3].
| Name | sandramycin |
|---|
| Description | Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity[1][2][3]. |
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| Related Catalog | |
| Target |
Traditional Cytotoxic Agents |
| In Vitro | Sandramycin has antimicrobial activity wtih MIC values of 0.024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Bacillus subtilis (Rec+) A22508-2, B. subtilis (Rec-) A22509-2-2, Staphylocccus aureus 209P-A9497, S. aureus (echinomycin-resistant) A9628, Streptococcus faecalis A96 1 1, Escherichia coli A151 19 and E. coli (actinomycin-sensitive) A21780 (AS-19), respectively[1]. Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC50 values of 0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively[2]. |
| In Vivo | Sandramycin (0.0125-1.6 mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice[1]. Animal Model: CDF1 female mice injected with leukemia P388 cells[1] Dosage: 0.0125 mg/kg, 0.025 mg/kg, 0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg, 0.4 mg/kg, 0.8 mg/kg, 1.6 mg/kg Administration: Intraperitoneal injection; daily; for 5 days Result: Was moderately active in vivo against leukemia P388 in mice. |
| References |
| Density | 1.42g/cm3 |
|---|---|
| Boiling Point | 1518.4ºC at 760 mmHg |
| Molecular Formula | C60H76N12O16 |
| Molecular Weight | 1221.32000 |
| Flash Point | 872.1ºC |
| Exact Mass | 1220.55000 |
| PSA | 357.10000 |
| LogP | 1.13540 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.659 |
| Storage condition | -20°C |