Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

100853-58-5

100853-58-5 structure

Name: cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat)
Chemical Name: h-thr-thr-tyr-ala-asp-phe-ile-ala-ser-gly-arg-thr-gly-arg-arg-asn-ala-ile-nh2
CAS Number: 100853-58-5
Molecular Formula: C₈₄H₁₃₇N₂₉O₂₆
Molecular Weight: 1969.17000
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK PKA
Create Date: 2016-07-19 04:40:18
Modify Date: 2025-08-25 18:14:17
PKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors[1][2].

Name	h-thr-thr-tyr-ala-asp-phe-ile-ala-ser-gly-arg-thr-gly-arg-arg-asn-ala-ile-nh2
Synonyms	PKI (5-22),AMIDE CAMP-DEPENDENT PROTEIN KINASE INHIBITOR (5-22) AMIDE PKI-a (5-22) aMide (huMan,Mouse,rabbit,rat),Wiptide cAMP-Dependent Protein Kinase Inhibitor (5-22),amide,Wiptide WIPTIDE PROTEIN KINASE A INHIBITOR (5-22) AMIDE TTYADFIASGRTGRRNAI-NH2 CAMP DEPENDENT PK INHIBITOR (5-22) AMIDE PKA INHIBITOR (5-22) AMIDE THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2 THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-HIS-ASP: TTYADFIASGRTGRRNAIHD

Description	PKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Neurological Disease
In Vitro	PKI(5-22)amide (1 μM; 1 min) fails to block CRF1 receptor (100 nM; 30 min) desensitization in Y-79 cells permeabilized with Streptolysin O (HY-135416)[1].
References	[1]. Dautzenberg FM, et al. GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation. Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R935-46. [2]. Reed J, et al. Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase. Biochem J. 1989 Dec 1;264(2):371-80.