DC Chemicals Limited
China
Product Name: Thozalinone
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Thozalinone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

655-05-0

655-05-0 structure

Name: Thozalinone
Chemical Name: 2-(dimethylamino)-5-phenyl-1,3-oxazol-4-one
CAS Number: 655-05-0
Molecular Formula: C₁₁H₁₂N₂O₂
Molecular Weight: 204.23
Create Date: 2018-09-10 17:09:18
Modify Date: 2025-08-27 13:26:12
Thozalinone also known as 5phenyl-2-dimethylamino-2-oxazolin-4-one, is an excitant with activity against Tetrabenazine depression. Thozalinone has unique properties distinguishing them from the sympathomimetic amines[1].

Name	2-(dimethylamino)-5-phenyl-1,3-oxazol-4-one
Synonyms	2-Dimethylamino-5-phenyl-4-oxazolinon-(4) Tozalinona [INN-Spanish] 2-Oxazolin-4-one,2-(dimethylamino)-5-phenyl 5-Phenyl-2-dimethylamino-2-oxazolin-4-on 2-(Dimethylamino)-5-phenyl-2-oxazolin-4-one 2-Dimethylamino-5-phenyl-4-oxo-2-oxazolin 2-Dimethylamino-4-oxo-5-phenyl-oxazolin Tozalinonum [INN-Latin] Stimsen 2-dimethylamino-5-phenyl-oxazol-4-one Tozalinone THOZALINONE

Description	Thozalinone also known as 5phenyl-2-dimethylamino-2-oxazolin-4-one, is an excitant with activity against Tetrabenazine depression. Thozalinone has unique properties distinguishing them from the sympathomimetic amines[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Greenblatt EN, et al. Some pharmacologic properties of thozalinone, a new excitant. Toxicol Appl Pharmacol. 1965 Jul;7(4):566-78.

Density	1.19g/cm3
Boiling Point	294.8ºC at 760 mmHg
Melting Point	134.5ºC
Molecular Formula	C₁₁H₁₂N₂O₂
Molecular Weight	204.23
Flash Point	132.1ºC
Exact Mass	204.09000
PSA	41.90000
LogP	0.63770
Index of Refraction	1.584
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ5775000

CHEMICAL NAME :: 2-Oxazolin-4-one, 2-(dimethylamino)-5-phenyl-

CAS REGISTRY NUMBER :: 655-05-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H12-N2-O2

MOLECULAR WEIGHT :: 204.25

WISWESSER LINE NOTATION :: T5NV DO CHJ CR& EN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3000 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Behavioral - somnolence (general depressed activity)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1240 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 570 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

HS Code	2934999090

2152-34-3

124-40-3

655-05-0

Literature: Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1679 - 1685

2152-34-3

77-78-1

655-05-0

Literature: Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1686 - 1691

19331-89-6

124-40-3

655-05-0

Literature: Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1679 - 1685

100-52-7

655-05-0

Literature: Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1679 - 1685

1467-79-4

774-40-3

655-05-0

Literature: Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1679 - 1685

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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