325965-23-9

325965-23-9 structure

Name: Linopristin
Chemical Name: Linopristin
CAS Number: 325965-23-9
Molecular Formula: C₅₀H₆₃N₉O₁₀
Molecular Weight: 950.09000
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-05-29 16:01:56
Modify Date: 2024-01-10 11:13:37
Linopristin is a kind of type B streptogramin antibiotics. Linopristin, together with type A, Flopristin, to form the streptogramin combination NXL 103. Linopristin exhibit synergistic antimicrobial activity against certain pathogenic bacteria with Flopristin. The preference ratio of Linopristin/Flopristin is 30:70 (w/w) or 70 μM Linopristin +120 μM Flopristin[1].

Name	Linopristin
Synonyms	UNII-312V80FR4J Linopristin [INN] N-((6R,9S,10R,13S,15aS,22S,24aS)-22-((4-(dimethylamino)phenyl)methyl)-6-ethyl-10,23-dimethyl-18-((morpholin-4-yl)methyl)-5,8,12,15,21,24-hexaoxo-13-phenyl-1,2,3,5,6,7,8,9,10,11,12,13,14,15,15a,16,19,21,22,23,24,24a-docosahydropyrido(2,1-f)pyrrolo(2,1-l)(1,4,7,10,13,16)oxapentaazacyclononadecin-9-yl)-3-hydroxypyridine-2-carboxamide

Description	Linopristin is a kind of type B streptogramin antibiotics. Linopristin, together with type A, Flopristin, to form the streptogramin combination NXL 103. Linopristin exhibit synergistic antimicrobial activity against certain pathogenic bacteria with Flopristin. The preference ratio of Linopristin/Flopristin is 30:70 (w/w) or 70 μM Linopristin +120 μM Flopristin[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Linopristin (0-64 μg/mL) 对革兰氏阴性病原菌的抑菌作用不大，原因是其外细胞膜渗透性差[1]。 Linopristin 抑制粪肠球菌、金黄色葡萄球菌和肺炎葡萄球菌的生长，IC50 分别为 8 μg/mL、32 μg/mL 和 4 μg/mL[1]。
References	[1]. Noeske J, et al. Synergy of streptogramin antibiotics occurs independently of their effects on translation. Antimicrob Agents Chemother. 2014 Sep;58(9):5269-79.