220757-88-0

220757-88-0 structure

Name: tCFA15
Chemical Name: 3-(15-hydroxypentadecyl)-2,4,4-trimethylcyclohex-2-en-1-one
CAS Number: 220757-88-0
Molecular Formula: C₂₄H₄₄O₂
Molecular Weight: 364.60500
Catalog: Signaling Pathways Stem Cell/Wnt Notch
Create Date: 2017-01-15 22:27:18
Modify Date: 2024-01-04 12:54:39
tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.

Name	3-(15-hydroxypentadecyl)-2,4,4-trimethylcyclohex-2-en-1-one
Synonyms	tCFA15

Description	tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Notch Research Areas >> Neurological Disease
Target	Notch1[1]
In Vitro	tCFA15 (10 nM-1 μM) dose-dependently affects the differentiation of neural stem cell-derived neurospheres by promoting neurons at the expense of astrocytes, and such effect is via Notch1. tCFA15 (1 μM) specifically decreases the level of Notch1 mRNA in spheres, and such an effect is also observed in decreases Notch1 expression in neuronal and glial cell cultures[1]. tCFA15 stimulates arginine vasopressin secretion in nerve terminals of the neurohypophysis[2].
References	[1]. Bouissac J, et al. tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol, affects neural stem fate and differentiation by modulating Notch1 activity. Eur J Pharmacol. 2013 Oct 15;718(1-3):383-92. [2]. Girlanda-Junges C, et al. 3-(15-Hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2537-9.