53943-88-7

53943-88-7 structure

Name: Letosteine
Chemical Name: 2-[2-(2-ethoxy-2-oxoethyl)sulfanylethyl]-1,3-thiazolidine-4-carboxylic acid
CAS Number: 53943-88-7
Molecular Formula: C₁₀H₁₇NO₄S₂
Molecular Weight: 279.38
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-03-21 08:00:00
Modify Date: 2025-08-25 14:45:53
Letosteine is an orally active, potent and safe expectorant. Letosteine dissolves bronchial mucus and reduces respiratory inflammation symptoms, and restores gas exchanges and natural defense mechanisms in the lung. Letosteine can be used for acute or chronic respiratory diseases (such as bronchopneumopathies) research[1][2][3].

Name	2-[2-(2-ethoxy-2-oxoethyl)sulfanylethyl]-1,3-thiazolidine-4-carboxylic acid
Synonyms	Viscotiol Letosteine Letosteinum Letosteina

Description	Letosteine is an orally active, potent and safe expectorant. Letosteine dissolves bronchial mucus and reduces respiratory inflammation symptoms, and restores gas exchanges and natural defense mechanisms in the lung. Letosteine can be used for acute or chronic respiratory diseases (such as bronchopneumopathies) research[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology
In Vivo	Letosteine (Sprague-Dawley rats, 20 mg/kg, IV or Orally, once) is rapidly excreted with mainly in urine[4]. Animal Model: Sprague-Dawley rats Dosage: 20 mg/kg Administration: IV or Orally, once Result: Rapidly was excreted with mainly in urine. More than 86% of the administered [14C]-radioactivity was recovered in urine within 72 h, 5-7% of the administered [14C]-radioactivity was recovered as 14CO2 in the expired air.
References	[1]. [1]Jia L. Letosteine. John Wiley & Sons, Ltd, 2014. [2]. [2] Macquet V, et al. A new contribution to the treatment of chronic bronchopneumopathies: letosteine. Lille Med. 1979;24(9):735-738. [3]. [3] Zhou Y, et al. Efficacy and safety of letosteine in the treatment of sputum thickening and expectoration difficulty in patients with respiratory diseases: a multicenter, randomized, double-masked, double dummy, positive drug parallel controlled trial. Pharmazie. 2014;69(11):842-849. [4]. [4] Gachon F, et al. Disposition and metabolism of letosteine in rats. Drug Metab Dispos. 1988;16(6):853-857.

Hazard Codes	Xn
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%