423763-19-3

423763-19-3 structure
423763-19-3 structure
  • Name: Benzyl-PEG7-alcohol
  • Chemical Name: 2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
  • CAS Number: 423763-19-3
  • Molecular Formula: C21H36O8
  • Molecular Weight: 416.50600
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2016-11-08 01:06:48
  • Modify Date: 2024-01-04 12:40:35
  • Benzyl-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonyms 1-Phenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-ol
monobenzyl heptaethylene glycol
Heptaethylene glycol Monobenzyl ether
Benzyl-PEG7-alcohol
Description Benzyl-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.099±0.06 g/cm3
Boiling Point 508.4±45.0 °C
Molecular Formula C21H36O8
Molecular Weight 416.50600
Exact Mass 416.24100
PSA 84.84000
LogP 1.29510
HS Code 2909499000

~49%

423763-19-3 structure

423763-19-3

Literature: James, Kenneth D. Patent: US2008/207505 A1, 2008 ; Location in patent: Page/Page column 32 ;

~99%

423763-19-3 structure

423763-19-3

Literature: Burns, Christopher J.; Field, Leslie D.; Morgan, Jacqueline; Petteys, Brian J.; Prashar, Jognandan; Ridley, Damon D.; Sandanayake, K.R.A. Samankumara; Vignevich, Valentina Australian Journal of Chemistry, 2001 , vol. 54, # 7 p. 431 - 438

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423763-19-3 structure

423763-19-3

Literature: French, Alister C.; Thompson, Amber L.; Davis, Benjamin G. Angewandte Chemie - International Edition, 2009 , vol. 48, # 7 p. 1248 - 1252

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423763-19-3 structure

423763-19-3

Literature: Pilkington-Miksa, Michael A.; Sarkar, Supti; Writer, Michele J.; Barker, Susie E.; Shamlou, Parviz Ayazi; Hart, Stephen L.; Hailes, Helen C.; Tabor, Alethea B. European Journal of Organic Chemistry, 2008 , # 17 p. 2900 - 2914

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423763-19-3 structure

423763-19-3

Literature: Burns, Christopher J.; Field, Leslie D.; Morgan, Jacqueline; Petteys, Brian J.; Prashar, Jognandan; Ridley, Damon D.; Sandanayake, K.R.A. Samankumara; Vignevich, Valentina Australian Journal of Chemistry, 2001 , vol. 54, # 7 p. 431 - 438

~%

423763-19-3 structure

423763-19-3

Literature: Burns, Christopher J.; Field, Leslie D.; Morgan, Jacqueline; Petteys, Brian J.; Prashar, Jognandan; Ridley, Damon D.; Sandanayake, K.R.A. Samankumara; Vignevich, Valentina Australian Journal of Chemistry, 2001 , vol. 54, # 7 p. 431 - 438

~%

423763-19-3 structure

423763-19-3

Literature: Burns, Christopher J.; Field, Leslie D.; Morgan, Jacqueline; Petteys, Brian J.; Prashar, Jognandan; Ridley, Damon D.; Sandanayake, K.R.A. Samankumara; Vignevich, Valentina Australian Journal of Chemistry, 2001 , vol. 54, # 7 p. 431 - 438
HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%