916047-16-0

916047-16-0 structure

Name: CAY10595
Chemical Name: 2-[5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxospiro[indole-3,3'-pyrrolidine]-1-yl]acetic acid
CAS Number: 916047-16-0
Molecular Formula: C₂₀H₁₃Cl₂FN₂O₅
Molecular Weight: 451.232
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2017-11-19 06:28:21
Modify Date: 2024-01-08 13:09:24
CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.

Name	2-[5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxospiro[indole-3,3'-pyrrolidine]-1-yl]acetic acid
Synonyms	[5-Chloro-1'-(5-chloro-2-fluorobenzyl)-2,2',5'-trioxospiro[indole-3,3'-pyrrolidin]-1(2H)-yl]acetic acid Spiro-indolinone analogue,71 Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-

Description	CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
Target	CRTH2/DP2 Receptor:10 nM (Ki)
In Vitro	CAY10595 (compound 71) is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM[1].
In Vivo	Administration of the DP2 antagonist CAY10595 slightly delays the development of CIA. Treatment with CAY10595 reduces IgG2a anti-CII levels without modification of IgG anti-CII levels[2].
References	[1]. Crosignani S, et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J Med Chem. 2008 Apr 10;51(7):2227-43. [2]. Maicas N, et al. Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis. Arthritis Rheum. 2012 Jan;64(1):130-40.