872726-44-8
872726-44-8 structure
- Name: NSC 721648
- Chemical Name: 2-(3,4-dimethoxyphenyl)-5-fluoro-1,3-benzothiazole
- CAS Number: 872726-44-8
- Molecular Formula: C15H12FNO2S
- Molecular Weight: 289.325
- Catalog: Research Areas Cancer
- Create Date: 2016-07-19 01:43:30
- Modify Date: 2025-08-27 12:53:28
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GW 610 (NSC 721648), an antitumor agent, shows potent and selective anticancer activity against lung, colon, and breast cancer cell lines[1][2][3].
| Name | 2-(3,4-dimethoxyphenyl)-5-fluoro-1,3-benzothiazole |
|---|---|
| Synonyms |
unii-x3xwa9lq3q
2-(3,4-Dimethoxyphenyl)-5-fluoro-1,3-benzothiazole gw 610 Benzothiazole, 2-(3,4-dimethoxyphenyl)-5-fluoro- |
| Description | GW 610 (NSC 721648), an antitumor agent, shows potent and selective anticancer activity against lung, colon, and breast cancer cell lines[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | GW 610 inhibits the proliferation of MCF-7, MDA 468, KM 12, and HCC 2998 cells, with GI50s of <0.1 nM, <0.1 nM, 290 nM, and 0.25 nM, respectively[1]. GW 610 (0.1-1 μM) induces CYP1A1 mRNA and protein in MDA-MB-468, MCF-7, KM12, and HCC2998 cells, whereas CYP2S1 and CYP2W1 are induced only in breast cancer cells[3]. Western Blot Analysis[3] Cell Line: MDA-MB-468, MCF-7, KM12, and HCC2998 cells Concentration: 0.1, 1 μM Incubation Time: 48 hours Result: Induced CYP1A1 mRNA and protein in all cell lines including KM12 and HCC2998 CRC cells. Induced CYP2S1 and CYP2W1 mRNA and protein expression in MDA-MB-468 and MCF-7 breast cancer cells. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 422.8±55.0 °C at 760 mmHg |
| Molecular Formula | C15H12FNO2S |
| Molecular Weight | 289.325 |
| Flash Point | 209.5±31.5 °C |
| Exact Mass | 289.057281 |
| PSA | 59.59000 |
| LogP | 4.70 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.619 |
|
~90%
872726-44-8 |
| Literature: Wang, Min; Gao, Mingzhang; Mock, Bruce H.; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8599 - 8607 |
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~65%
872726-44-8 |
| Literature: Prasad; Sekar Organic and Biomolecular Chemistry, 2013 , vol. 11, # 10 p. 1659 - 1665 |
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~%
872726-44-8 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 14, # 24 p. 8599 - 8607 |
|
~%
872726-44-8 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 14, # 24 p. 8599 - 8607 |
|
~%
872726-44-8 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 14, # 24 p. 8599 - 8607 |
| Precursor 5 | |
|---|---|
| DownStream 0 | |