862891-04-1

862891-04-1 structure

Name: HMB-Val-Ser-Leu-VE
Chemical Name: HMB-Val-Ser-Leu-VE
CAS Number: 862891-04-1
Molecular Formula: C₂₆H₃₉N₃O₇
Molecular Weight: 505.60
Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
Create Date: 2017-01-13 19:27:35
Modify Date: 2025-08-25 12:49:26
HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC50 of 0.033 μM[1].

Name	HMB-Val-Ser-Leu-VE
Synonyms	N-(3-Hydroxy-2-methylbenzoyl)-L-valyl-N-[(2E,4S)-1-ethoxy-6-methyl-1-oxo-2-hepten-4-yl]-L-serinamide N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(2E,4S)-1-ethoxy-6-methyl-1-oxohept-2-en-4-yl]-L-serinamide L-Serinamide, N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(1S,2E)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-buten-1-yl]-

Description	HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC50 of 0.033 μM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Others
Target	IC50: prototype vinyl ester[1]
References	[1]. Anna Baldisserotto, et al. C-terminal constrained phenylalanine as a pharmacophoric unit in peptide-based proteasome inhibitors. Eur J Med Chem. 2008 Jul;43(7):1403-11.