65974-52-9
65974-52-9 structure
- Name: Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester
- Chemical Name: dimethyl 2-[(2-nitrophenyl)methylidene]propanedioate
- CAS Number: 65974-52-9
- Molecular Formula: C12H11NO6
- Molecular Weight: 265.21900
- Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
- Create Date: 2016-12-09 02:13:12
- Modify Date: 2025-08-31 13:27:36
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NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1].
| Name | dimethyl 2-[(2-nitrophenyl)methylidene]propanedioate |
|---|---|
| Synonyms |
HMS2882B21
2'-nitrobenzylidenemalonic acid dimethyl ester dimethyl 2-nitrobenzylidenemalonate ortho-nitrobenzylidenmalonsaeuredimethylester |
| Description | NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.335g/cm3 |
|---|---|
| Boiling Point | 361.7ºC at 760mmHg |
| Molecular Formula | C12H11NO6 |
| Molecular Weight | 265.21900 |
| Flash Point | 151.8ºC |
| Exact Mass | 265.05900 |
| PSA | 98.42000 |
| LogP | 1.84740 |
| Index of Refraction | 1.578 |
|
~97%
65974-52-9 |
| Literature: Zhao, Xue Zhi; Smith, Steven J.; Metifiot, Mathieu; Johnson, Barry C.; Marchand, Christophe; Pommier, Yves; Hughes, Stephen H.; Burke Jr., Terrence R. Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1573 - 1582 |
|
~%
65974-52-9 |
| Literature: Takeda Chemical Industries, Ltd. Patent: US6329389 B1, 2001 ; |
| Precursor 3 | |
|---|---|
| DownStream 1 | |
![2-[(2-nitrophenyl)methylidene]propanedioic acid structure](https://image.chemsrc.com/caspic/077/103582-31-6.png)