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96020-91-6

96020-91-6 structure
96020-91-6 structure
  • Name: Eflornithine (hydrochloride, hydrate)
  • Chemical Name: DL-α-Difluoromethylornithine Hydrochloride Monohydrate
  • CAS Number: 96020-91-6
  • Molecular Formula: C6H15ClF2N2O3
  • Molecular Weight: 236.64500
  • Catalog: Research Areas Others
  • Create Date: 2018-04-22 08:00:00
  • Modify Date: 2025-08-21 19:02:19
  • Eflornithine hydrochloride, hydrate is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
Name DL-α-Difluoromethylornithine Hydrochloride Monohydrate
Synonyms 2,5-diamino-2-(difluoromethyl)pentanoic acid,hydrate,hydrochloride
Eflornithine (hydrochloride, hydrate)
Description Eflornithine hydrochloride, hydrate is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
Related Catalog
In Vivo Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4].
Animal Admin Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (-50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days[3].
References

[1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52.

[2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202.

[3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501.

[4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312.
Density 1.293g/cm3
Boiling Point 347ºC at 760mmHg
Melting Point >210ºC (dec.)
Molecular Formula C6H15ClF2N2O3
Molecular Weight 236.64500
Flash Point 163.7ºC
Exact Mass 236.07400
PSA 98.57000
LogP 1.91080
Storage condition 2~8°C
HS Code 2922499990
HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
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