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59-32-5

59-32-5 structure
59-32-5 structure
  • Name: Chloropyramine
  • Chemical Name: N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
  • CAS Number: 59-32-5
  • Molecular Formula: C16H20ClN3
  • Molecular Weight: 289.80300
  • Catalog: API Antiallergic Antihistamine
  • Create Date: 2018-04-14 08:00:00
  • Modify Date: 2025-08-26 10:43:58
  • Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma[1][2].
Name N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
Synonyms Chlorneoantergan
Avapena
Halopyramine
Anaphylline
Suprastin
Synpen
N-[(4-chlorophenyl)methyl]-N-[2-(dimethylamino)ethyl]pyridin-2-amine
Synopen
N-(4-Chlor-benzyl)-N',N'-dimethyl-N-<2>pyridyl-ethylendiamin
N-[(4-chlorophenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine
Chloropyramine
Chlorpyraminum
N-(4-Chlor-benzyl)-N',N'-dimethyl-N-[2]pyridyl-aethylendiamin
Chlorpyramine
N-(4-chloro-benzyl)-N',N'-dimethyl-N-[2]pyridyl-ethylenediamine
EINECS 200-421-1
Description Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma[1][2].
Related Catalog
Target

H1 Receptor

In Vitro Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines[1]. Western Blot Analysis[1] Cell Line: Breast cancer cell lines Concentration: 25 or 50 μM Incubation Time: 24 h Result: Increased SASH1 expression in breast cancer cell lines. Apoptosis Analysis[1] Cell Line: T47D, MDA-MB-231 and BT-54 cells Concentration: 50 μM Incubation Time: 48 h Result: Induced apoptosis in breast cancer cell lines.
In Vivo Chloropyramine (i.p.; 10 mg/kg) abolishes hypothermia in rats[2]. Animal Model: Rats[2] Dosage: 10 mg/kg Administration: Intraperitoneal Result: Reduced histamine-induced hypothermia.
Density 1.158g/cm3
Boiling Point 413.5ºC at 760 mmHg
Melting Point 25°C
Molecular Formula C16H20ClN3
Molecular Weight 289.80300
Flash Point 203.9ºC
Exact Mass 289.13500
PSA 19.37000
LogP 3.30320
Index of Refraction 1.6
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US6320000
CHEMICAL NAME :
Pyridine, 2-((p-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-
CAS REGISTRY NUMBER :
59-32-5
BEILSTEIN REFERENCE NO. :
0257085
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C16-H20-Cl-N3
MOLECULAR WEIGHT :
289.84
WISWESSER LINE NOTATION :
T6NJ BN2N1&1&1R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
920 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
104 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
32500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
354 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
79200 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
24100 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
108 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
142 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,131,1957
Hazard Codes Xi
109-04-6 structure

109-04-6

65875-44-7 structure

65875-44-7

~%

59-32-5 structure

59-32-5

Literature: DE931828 , ; DRP/DRBP Org.Chem.
23826-72-4 structure

23826-72-4

~%

59-32-5 structure

59-32-5

Literature: DE931828 , ; DRP/DRBP Org.Chem.
22881-33-0 structure

22881-33-0

~%

59-32-5 structure

59-32-5

Literature: US2607778 , ;
109475-91-4 structure

109475-91-4

~%

59-32-5 structure

59-32-5

Literature: Acta Chimica Academiae Scientiarum Hungaricae, , vol. 15, p. 265,269
504-29-0 structure

504-29-0

~%

59-32-5 structure

59-32-5

Literature: Acta Chimica Academiae Scientiarum Hungaricae, , vol. 15, p. 265,269
101436-54-8 structure

101436-54-8

~%

59-32-5 structure

59-32-5

Literature: Acta Chimica Academiae Scientiarum Hungaricae, , vol. 15, p. 265,269
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