BioBioPha
China
Product Name: palmatine
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Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: palmatine
Price: ￥198.0/20mg ￥238.0/5g ￥908.0/25g
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Palmatine
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Palmatine
Price: ￥Inquiry/1kg
Purity: 99.5%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Palmatine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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3486-67-7

3486-67-7 structure

Name: palmatine
Chemical Name: palmatine
CAS Number: 3486-67-7
Molecular Formula: C₂₁H₂₂NO₄+
Molecular Weight: 352.403
Catalog: API Synthetic anti-infective drugs Natural source anti-infectives
Create Date: 2018-03-13 08:00:00
Modify Date: 2024-01-02 18:03:46
Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1].

Name	palmatine
Synonyms	Calystigine 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxyberbinium MFCD00221758 palmatine Burasaine 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium palmatin berbericinine 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxyberbinium Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy- o,o-dimethyldemethyleneberberine Hindarinine 5,6-Dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium Common fibraurea stem

Description	Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO) Research Areas >> Inflammation/Immunology
Target	IDO1
In Vitro	Palmatine exhibits more potent IDO-1 inhibitory activity , which IC50 on rhIDO-1 is 157μM, and on HEK 293-hIDO-1 is 3 μM[1].
In Vivo	Palmatine (oral administration; 50 or 100 mg/kg, 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity[1]. Animal Model: DSS- induced Colitis BALB/c mice model[1] Dosage: 50 or 100 mg/kg; 7 days Administration: Oral administration Result: Ameliorated DSS-induced colitis and prevented infiltration of inflammatory cells.
References	[1]. Zhang XJ, et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.Pharmacol Res. 2018 Nov;137:34-46.

Melting Point	205ºC
Molecular Formula	C₂₁H₂₂NO₄+
Molecular Weight	352.403
Exact Mass	352.154327
PSA	40.80000
LogP	-1.12

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9890000

CHEMICAL NAME :: Berbinium, 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-

CAS REGISTRY NUMBER :: 3486-67-7

BEILSTEIN REFERENCE NO. :: 1555498

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H22-N-O4

MOLECULAR WEIGHT :: 352.44

WISWESSER LINE NOTATION :: T D6 B666 KN&TT&J GO1 HO1 PO1 QO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,129,1968

Hazard Codes	Xi
HS Code	2933990090

131543-46-9

47355-66-8

~60%

3486-67-7

Literature: Bian, Xiaoli; He, Langchong; Yang, Guangde Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1380 - 1383

221527-72-6

~20%

3486-67-7

Literature: Wafo, Pascal; Nyasse, Barthelemy; Fontaine, Catherine Phytochemistry, 1999 , vol. 50, # 2 p. 279 - 281

109806-78-2

3486-67-7

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 - 1383

120-20-7

3486-67-7

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 - 1383

86-51-1

3486-67-7

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 - 1383

Precursor 2
120-20-7 86-51-1
DownStream 1
16176-68-4

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3486-67-7	4880-79-9
947153-64-2	10605-02-4
131-04-4	171869-95-7