Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Trometamol
Price: ￥6788.0/25kg ￥1688.0/5kg ￥218.0/500g
Purity: 99.9%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Tromethamine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Trometamol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Trometamol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

77-86-1

77-86-1 structure

Name: Trometamol
Chemical Name: Trometamol
CAS Number: 77-86-1
Molecular Formula: C₄H₁₁NO₃
Molecular Weight: 121.135
Catalog: API Water, electrolyte and acid-base balance regulator Acid-base balance regulator
Create Date: 2018-05-08 08:00:00
Modify Date: 2024-01-02 19:07:23
Trometamol is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. Trometamol is an effective amine compound for pH control in the physiological range[1].

Name	Trometamol
Synonyms	EINECS 201-064-4 Tham-E THAM Talatrol Trizma TRIS 8VTE 1L thamset MFCD00004679 riladyl TRISMAT Tromethamine Pehanorm tris base

Description	Trometamol is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. Trometamol is an effective amine compound for pH control in the physiological range[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Nahas GG, et al. Guidelines for the treatment of acidaemia with THAM. Drugs. 1998 Feb;55(2):191-224.

Density	1.3±0.1 g/cm3
Boiling Point	357.0±37.0 °C at 760 mmHg
Melting Point	167-172 °C(lit.)
Molecular Formula	C₄H₁₁NO₃
Molecular Weight	121.135
Flash Point	169.7±26.5 °C
Exact Mass	121.073891
PSA	86.71000
LogP	-1.38
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.544
Storage condition	2-8°C
Stability	Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.
Water Solubility	550 g/L (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY2900000

CHEMICAL NAME :: 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-

CAS REGISTRY NUMBER :: 77-86-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H11-N-O3

MOLECULAR WEIGHT :: 121.16

WISWESSER LINE NOTATION :: Q1XZ1Q1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 110,653,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,419,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 17,217,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - coma

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 22,315,1940 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81165 No. of Facilities: 850 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 7274 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81165 No. of Facilities: 2296 (estimated) No. of Industries: 9 No. of Occupations: 22 No. of Employees: 40897 (estimated) No. of Female Employees: 30773 (estimated)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	TY2900000
HS Code	29221980

79-06-1

77-86-1

Literature: Methods in Enzymology, , vol. 529, p. 171 - 184

19320-52-6

114444-46-1

124225-44-1

77-86-1

Literature: Journal of the American Chemical Society, , vol. 112, # 2 p. 779 - 786

126-11-4

77-86-1

Literature: Industrial and Engineering Chemistry, , vol. 40, p. 507 Industrial and Engineering Chemistry, , vol. 32, p. 891

19320-52-6

77-86-1

Literature: Journal of Chemical Thermodynamics, , vol. 19, # 4 p. 385 - 390

Precursor 2
79-06-1 126-11-4
DownStream 10
108367-50-6 146651-71-0 18212-81-2 59-67-6
100-02-7 6323-83-7 363-72-4 50-00-0
96-26-4 6850-28-8

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

77-86-1	130349-12-1
136760-04-8	92451-00-8
14504-24-6	38562-01-5
38362-01-5	60254-96-8
78964-85-9	58551-69-2