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121-66-4

121-66-4 structure
121-66-4 structure
Name 2-Amino-5-nitrothiazole
Synonyms 2-Amino-5-nitrothiazole
2-Thiazolamine, 5-nitro-
5-nitro-2-thiazolylamin
5-Nitrothiazol-2-amine
5-Nitro-1,3-thiazol-2-amine
MFCD00005326
EINECS 204-490-9
2-AMINO-5-NITRO THIAZOLE
Density 1.7±0.1 g/cm3
Boiling Point 345.1±15.0 °C at 760 mmHg
Melting Point 195-200 °C (dec.)(lit.)
Molecular Formula C3H3N3O2S
Molecular Weight 145.140
Flash Point 162.5±20.4 °C
Exact Mass 144.994598
PSA 112.97000
LogP 0.83
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.705
Stability Stable. Incompatible with strong acids, strong oxidizing agents, acid chlorides, acid anhydrides.
Water Solubility <0.1 g/100 mL at 20 ºC

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ2800000
CHEMICAL NAME :
Thiazole, 2-amino-5-nitro-
CAS REGISTRY NUMBER :
121-66-4
BEILSTEIN REFERENCE NO. :
0126797
LAST UPDATED :
199710
DATA ITEMS CITED :
24
MOLECULAR FORMULA :
C3-H3-N3-O2-S
MOLECULAR WEIGHT :
145.15
WISWESSER LINE NOTATION :
T5N CSJ BZ DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
23 gm/kg/46W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
600 mg/kg
SEX/DURATION :
male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
700 mg/kg
SEX/DURATION :
male 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
15600 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12(Suppl 13),103,1988 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,71,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,71,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P301 + P312 + P330-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R20/21/22;R40
Safety Phrases S26-S45-S24/25
RIDADR 2811
WGK Germany 3
RTECS XJ2800000
HS Code 2934100090
96-50-4 structure

96-50-4

~%

121-66-4 structure

121-66-4

Literature: Proceedings - Indian Academy of Sciences, Section A, , # 22 p. 362,376 Galenica Acta, , vol. 12, p. 249,252 Journal of Organic Chemistry, , vol. 20, p. 499,505
59024-01-0 structure

59024-01-0

~%

121-66-4 structure

121-66-4

Literature: Canadian Journal of Chemistry, , vol. 34, p. 1261,1267
140-40-9 structure

140-40-9

~%

121-66-4 structure

121-66-4

Literature: Proceedings - Indian Academy of Sciences, Section A, , # 22 p. 362,376 Yakugaku Zasshi, , vol. 72, p. 1020 Chem.Abstr., , p. 10286
2719-23-5 structure

2719-23-5

~%

121-66-4 structure

121-66-4

Literature: US2617809 , ;
96-50-4 structure

96-50-4

625-58-1 structure

625-58-1

~%

121-66-4 structure

121-66-4

Literature: Annali di Chimica Applicata, , vol. 38, p. 449,454
73430-27-0 structure

73430-27-0

17356-08-0 structure

17356-08-0

~%

121-66-4 structure

121-66-4

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 24 p. 7414 - 7417
HS Code 2934100090
Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
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