CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
DU8229050
-
CHEMICAL NAME :
-
4-Biphenylacetic acid
-
CAS REGISTRY NUMBER :
-
5728-52-9
-
BEILSTEIN REFERENCE NO. :
-
1211592
-
LAST UPDATED :
-
199612
-
DATA ITEMS CITED :
-
14
-
MOLECULAR FORMULA :
-
C14-H12-O2
-
MOLECULAR WEIGHT :
-
212.26
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
164 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
INFLD4 Inflammation. (Plenum Publishing Corp., 233 Spring St., New York, NY 10013) V.1- 1975- Volume(issue)/page/year: 1,415,1976
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
495 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2107,1986
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
148 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2107,1986
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
675 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2107,1986
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
508 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2107,1986
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
730 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2107,1986
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
320 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2107,1986
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
1280 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2107,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
900 mg/kg/30D-C
-
TOXIC EFFECTS :
-
Liver - other changes Blood - normocytic anemia Related to Chronic Data - death
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2107,1986
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
3640 mg/kg/26W-C
-
TOXIC EFFECTS :
-
Kidney, Ureter, Bladder - other changes Blood - changes in spleen Related to Chronic Data - death
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2107,1986 ** REPRODUCTIVE DATA **
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
540 mg/kg
-
SEX/DURATION :
-
female 17-22 day(s) after conception lactating female 21 day(s) post-birth
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - behavioral
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2153,1986
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
270 mg/kg
-
SEX/DURATION :
-
female 17-22 day(s) after conception lactating female 21 day(s) post-birth
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - behavioral
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2153,1986
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
360 mg/kg
-
SEX/DURATION :
-
female 6-17 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2142,1986
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
240 mg/kg
-
SEX/DURATION :
-
female 6-17 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
-
REFERENCE :
-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,2142,1986
|