61849-14-7

61849-14-7 structure

Name: Epoprostenol sodium
Chemical Name: prostacyclin sodium salt
CAS Number: 61849-14-7
Molecular Formula: C₂₀H₃₁NaO₅
Molecular Weight: 374.447
Catalog: API Hormone and endocrine-regulating drugs Prostaglandins
Create Date: 2018-07-14 12:10:26
Modify Date: 2024-01-02 10:32:04
Epoprostenol sodium (Prostaglandin I2 (sodium salt)), the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH)[1]. Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation[2].

Name	prostacyclin sodium salt
Synonyms	(5Z)-5-{(3aR,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxyoct-1-én-1-yl]hexahydro-2H-cyclopenta[b]fur-2-ylidène}pentanoate de sodium MFCD00135629 Natrium-(5Z)-5-{(3aR,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxyoct-1-en-1-yl]hexahydro-2H-cyclopenta[b]fur-2-yliden}pentanoat PGI2 Flolan Prostacyclin sodium EINECS 234-237-8 Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, sodium salt, (9α,11α,13E,15S)- (1:1) PG12-NA (5Z,9a,11a,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic Acid Sodium Salt U 53217A PGI2,SODIUM SALT Sodium PGI2 prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, monosodium salt, (5Z,9α,11α,13E,15S)- PGI2-NA PROSTAGLANDIN I2 Prostaglandin 12 PGI2 sodium sodium (5Z)-5-{(3aR,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxyoct-1-en-1-yl]hexahydro-2H-cyclopenta[b]furan-2-ylidene}pentanoate Epoprostenol sodium Sodium (9α,11α,13E,15S)-11,15-dihydroxy-6,9-epoxyprosta-5,13-dien-1-oate

Description	Epoprostenol sodium (Prostaglandin I2 (sodium salt)), the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH)[1]. Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation[2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Provencher S, et al.Quality of life, safety and efficacy profile of thermostable flolan in pulmonary arterialhypertension. PLoS One. 2015 Mar 20;10(3):e0120657.

Boiling Point	530.2ºC at 760mmHg
Melting Point	168-170 °C
Molecular Formula	C₂₀H₃₁NaO₅
Molecular Weight	374.447
Flash Point	182.1ºC
Exact Mass	374.206909
PSA	89.82000
LogP	2.07380
Storage condition	−20°C
Water Solubility	H2O: 1 mg/mL Hydrolyzes to 6-ketoprostaglandin F1α in aqueous solution.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332
Precautionary Statements	P261-P280-P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S22-S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3