780750-65-4
780750-65-4 structure
- Name: AZD-5672
- Chemical Name: N-[1-[(3R)-3-(3,5-difluorophenyl)-3-(4-methylsulfonylphenyl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
- CAS Number: 780750-65-4
- Molecular Formula: C32H38F2N2O5S2
- Molecular Weight: 632.78100
- Catalog: Signaling Pathways GPCR/G Protein CCR
- Create Date: 2016-12-09 04:44:30
- Modify Date: 2024-01-12 16:37:53
-
AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis[1][2][3].
| Name | N-[1-[(3R)-3-(3,5-difluorophenyl)-3-(4-methylsulfonylphenyl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide |
|---|---|
| Synonyms | unii-61xqn688tw |
| Description | AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
CCR5:0.32 nM (IC50) hERG:7.3 μM (IC50) hP-gp:32 μM (IC50) |
| In Vitro | AZD-5672 (0, 0.1, 0.3, 1, 3, 10, 30, and 100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner (mean apparent IC50: 32 μM) in Caco-2 cells[2]. |
| In Vivo | In vivo pharmaeokineties data for AZD-5672 (compound 1)[1] Species CIa (mL/min/kg) Vssa (L/kg) t1/2a (h) Fb (%) Rat 28 5.3 2.6 38 Dog 18 5.7 3.9 86 a AZD-5672 dosed 1-2 mg/kg i.v. b AZD-5672 dosed 2-5 mg/kg p.o. |
| References |
| Molecular Formula | C32H38F2N2O5S2 |
|---|---|
| Molecular Weight | 632.78100 |
| Exact Mass | 632.21900 |
| PSA | 108.59000 |
| LogP | 6.94890 |