BioBioPha
China
Product Name: O-Nornuciferine
Price: ￥1650.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

DC Chemicals Limited
China
Product Name: O-Nornuciferine
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

3153-55-7

3153-55-7 structure

3153-55-7 structure

Name: O-Nornuciferine
Chemical Name: (R)-1-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol
CAS Number: 3153-55-7
Molecular Formula: C₁₈H₁₉NO₂
Molecular Weight: 281.349
Catalog: Natural product Alkaloid
Create Date: 2016-11-18 01:49:30
Modify Date: 2024-01-04 11:47:52
O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor[1].

Name	(R)-1-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol
Synonyms	4H-Dibenzo[de,g]quinolin-2-ol, 5,6,6a,7-tetrahydro-1-methoxy-6-methyl-, (6aR)- (6aR)-1-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol

Description	O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	O-Nornuciferine has an IC50 of 7.91 μM in vitro hERG blockages measured in HEK293 cells[1]. O-Nornuciferine (100 μM) has 47% hERG channel inhibition in Xenopus oocytes by lotus alkaloids[1].
References	[1]. Ulrike Grienke, et al. Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids From Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements. J Agric Food Chem. 2015 Jun 17;63(23):5634-9.

Density	1.2±0.1 g/cm3
Boiling Point	451.4±45.0 °C at 760 mmHg
Melting Point	195-197℃ (ethyl acetate )
Molecular Formula	C₁₈H₁₉NO₂
Molecular Weight	281.349
Flash Point	226.8±28.7 °C
Exact Mass	281.141571
PSA	32.70000
LogP	3.36
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.634

Hazard Codes	Xi