1522004-70-1

1522004-70-1 structure

Name: Aphadilactone C
Chemical Name: (6S,6'S)-6,6'-((1E,1'E)-((4S,7S)-4-(5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)-2,2-dimethyl-3-oxo-2,3,4,5,6,7-hexahydrobenzofuran-4,7-diyl)bis(2-methylpent-1-ene-5,1-diyl))bis(4-methyl-5,6-dihydro-2H-pyran-2-one)
CAS Number: 1522004-70-1
Molecular Formula: C₄₀H₅₂O₈
Molecular Weight: 660.84
Catalog: Natural product Moss
Create Date: 2016-03-03 14:03:41
Modify Date: 2025-08-20 18:12:24
Aphadilactone C is a potent and selective DGAT-1 inhibitor with an IC50 of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC50 value of 170 nM[1].

Name	(6S,6'S)-6,6'-((1E,1'E)-((4S,7S)-4-(5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)-2,2-dimethyl-3-oxo-2,3,4,5,6,7-hexahydrobenzofuran-4,7-diyl)bis(2-methylpent-1-ene-5,1-diyl))bis(4-methyl-5,6-dihydro-2H-pyran-2-one)
Synonyms	(4S,7S)-4-(5,5-Dimethyl-4-oxo-4,5-dihydro-2-furanyl)-2,2-dimethyl-4,7-bis{(4E)-4-methyl-5-[(2S)-4-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-4-penten-1-yl}-4,5,6,7-tetrahydro-1-benzofuran-3(2H)-one 3(2H)-Benzofuranone, 4-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)-4,7-bis[(4E)-5-[(2S)-3,6-dihydro-4-methyl-6-oxo-2H-pyran-2-yl]-4-methyl-4-penten-1-yl]-4,5,6,7-tetrahydro-2,2-dimethyl-, (4S,7S)-

Description	Aphadilactone C is a potent and selective DGAT-1 inhibitor with an IC50 of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC50 value of 170 nM[1].
Related Catalog	Research Areas >> Infection
References	[1]. Jia Liu, et al. Aphadilactones A-D, four diterpenoid dimers with DGAT inhibitory and antimalarial activities from a Meliaceae plant. J Org Chem. 2014 Jan 17;79(2):599-607.

Hazard Codes	Xi