475231-21-1

475231-21-1 structure

Name: 3'-Hydroxypterostilbene
Chemical Name: 3'-Hydroxypterostilbene
CAS Number: 475231-21-1
Molecular Formula: C₁₆H₁₆O₄
Molecular Weight: 272.296
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-10-19 09:11:12
Modify Date: 2025-09-18 19:04:14
3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways[1].

Name	3'-Hydroxypterostilbene
Synonyms	1,2-Benzenediol, 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]- 4-[(E)-2-(3,5-Dimethoxyphenyl)vinyl]-1,2-benzenediol 4-[2-(3,5-dimethoxyphenyl)ethenyl]benzene-1,2-diol 4-(2-(3,5-dimethoxyphenyl)ethenyl)-1,2-benzenediol 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]benzene-1,2-diol 4-[(E)-2-(3,5-Dimethoxyphenyl)vinyl]benzene-1,2-diol (E)-4-(3,5-Dimethoxystyryl)benzene-1,2-diol

Description	3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
Target	Apoptosis[1] Autophagy[1]
References	[1]. Cheng TC, et al. Potent anti-cancer effect of 3'-hydroxypterostilbene in human colon xenograft tumors. PLoS One. 2014 Nov 12;9(11):e111814.