865536-65-8

865536-65-8 structure

Name: 4-oxo-4-HPR
Chemical Name: (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)nona-2,4,6,8-tetraenamide
CAS Number: 865536-65-8
Molecular Formula: C₂₆H₃₁NO₃
Molecular Weight: 405.53
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-08-12 18:19:28
Modify Date: 2025-09-06 09:14:32
4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1].

Name	(2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)nona-2,4,6,8-tetraenamide
Synonyms	4-oxo-4-HPR N-(4-Hydroxyphenyl)-4-oxoretinamide 4-oxo-N-(4-hydroxyphenyl)retinamide 3-Keto fenretinide 4-Oxo Fenretinide 4-Keto-4-HPR

Description	4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. VillaniMG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite,induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitiveand fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47. [2]. Villani MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.