Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: oxypertine
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153-87-7

153-87-7 structure

153-87-7 structure

Name: oxypertine
Chemical Name: oxypertine
CAS Number: 153-87-7
Molecular Formula: C₂₃H₂₉N₃O₂
Molecular Weight: 379.49500
Catalog: Research Areas Neurological Disease
Create Date: 2018-09-13 06:53:26
Modify Date: 2024-01-02 09:03:10
Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia[1][2][3].

Name	oxypertine
Synonyms	Integrin EINECS 205-818-3 Opertil Equipertine Forit

Description	Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Oxypertine (0.44 nM-26 μM, 15 min) antagonizes dopamine and 5-HT induced contractions of the rat isolated vas deferens[1]. Oxypertine (8.8 nM, 15 min) reduces the contractions evoked by transmural stimulation of the vas deferens[1].
In Vivo	Oxypertine (10 and 35 mg/kg, i.p.) causes an obvious dose-related depletion in the levels of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) in various discrete regions of the rat brain[2]. Oxypertine (0.625-20 mg/kg, i.p.) inhibits stereotyped behaviour induced by both amphetamine and apomorphine in rats[3]. Animal Model: Mice with chronic restraint stress[2] Dosage: 10, 35 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Increased the level of homovanillic acid in three discrete regions, i.e., the cortex, striatum and mid-brain. Inhibited Apomorphine-induced stereotypy. Animal Model: Mice with stereotyped behaviour induced by amphetamine (5.0 mg/kg i.p.) and apomorphine (1.0 mg/kg, s.c.)[3] Dosage: 0.625-20 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Reduced the content of dopamine in the striatum but increased the concentrations of homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC).

Density	1.157g/cm3
Boiling Point	555.5ºC at 760 mmHg
Molecular Formula	C₂₃H₂₉N₃O₂
Molecular Weight	379.49500
Flash Point	289.8ºC
Exact Mass	379.22600
PSA	40.73000
LogP	3.86110
Vapour Pressure	2.22E-12mmHg at 25°C
Index of Refraction	1.614

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL7170000

CHEMICAL NAME :: Indole, 5,6-dimethoxy-2-methyl-3-(2-(4-phenyl-1-piperazinyl)e thyl)-

CAS REGISTRY NUMBER :: 153-87-7

BEILSTEIN REFERENCE NO. :: 0899339

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H29-N3-O2

MOLECULAR WEIGHT :: 379.55

WISWESSER LINE NOTATION :: T56 BMJ C1 GO1 HO1 D2- AT6N DNTJ DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 154 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 26,186,1966

RIDADR	UN 3249
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%