Name | (+/-)-2-(p-methoxyphenoxy)propionic acid |
---|---|
Synonyms |
2-(4-Methoxyphenoxy)propanoic acid
PMP (±)-2-(p-Methoxyphenoxy)propionic acid UNII:K573UZ6O8U Propanoic acid, 2-(4-methoxyphenoxy)- 2-(4-Methoxyphenoxy)propionic acid |
Description | Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2]. |
---|---|
Related Catalog | |
Target |
T1R3[1] |
In Vitro | Lactisole (3-10 mM; 48 h) 在小鼠胰腺 β 细胞 MIN6 中抑制 Acesulfame-K、Sucralose (HY-N0614) 和 Glycyrrhizin (HY-N0184) 诱导的胰岛素分泌 (IC50~4 mM)[1]。 Lactisole (5 mM; 48 h) 可减弱由 Sucralos 和 Acesulfame-K 引起的细胞质 Ca2+ 浓度升高 ([Ca2+]c),而不影响细胞内 cAMP 浓度升高 ([cAMP]c)[1]。 |
Density | 1.2±0.1 g/cm3 |
---|---|
Boiling Point | 331.6±17.0 °C at 760 mmHg |
Molecular Formula | C10H12O4 |
Molecular Weight | 196.200 |
Flash Point | 130.3±14.4 °C |
Exact Mass | 196.073563 |
PSA | 55.76000 |
LogP | 1.65 |
Vapour Pressure | 0.0±0.8 mmHg at 25°C |
Index of Refraction | 1.521 |