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52238-35-4

52238-35-4 structure
52238-35-4 structure
  • Name: 9-Hydroxyellipticine hydrochloride
  • Chemical Name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol,hydrochloride
  • CAS Number: 52238-35-4
  • Molecular Formula: C17H15ClN2O
  • Molecular Weight: 298.76700
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
  • Create Date: 2016-06-21 15:07:41
  • Modify Date: 2025-08-27 17:20:11
  • 9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively[1][2][3].
Name 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol,hydrochloride
Synonyms Ellipticine,hydrochloride
ELLIPTICINE ANALOG
9-HE,HCl
9-Hydroxyellipticine HCl
9 OHE HCl
Description 9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively[1][2][3].
Related Catalog
Target

Topoisomerase II

In Vitro 9-Hydroxyellipticine (9HE) causes selective inhibition of p53 protein phospborylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 μM[4].
In Vivo 9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells[1]. Animal Model: Three- to five-month-old C57B1/6 male mice[1]. Dosage: 5 or 10 mg/kg. Administration: IP. Result: Resulted in chromosome clumping, chromatid aberrations, and micronuclei formation in murine bone marrow cells.
References

[1]. Renault G, et al. In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells. Toxicol Appl Pharmacol. 1987 Jun 30;89(2):281-6.

[2]. Saeki K, et al. Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart. Jpn J Pharmacol. 2002 May;89(1):21-8.

[3]. Naoya Sato, et al. Synthesis and in vitro Antitumor Activity of 9-Hydroxyellipticine Derivatives with Glucose Conjugation via Triazolylmethyl Succinate Linker. Heterocycle, Vol. 92, NO 4, 2016.

[4]. Ohashi M, et al. Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn J Cancer Res. 1995 Sep;86(9):819-27.
Density 1.349g/cm3
Boiling Point 557.7ºC at 760mmHg
Molecular Formula C17H15ClN2O
Molecular Weight 298.76700
Flash Point 291.1ºC
Exact Mass 298.08700
PSA 48.91000
LogP 4.99370
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