149488-17-5

149488-17-5 structure

Name: Trovirdine
Chemical Name: Trovirdine
CAS Number: 149488-17-5
Molecular Formula: C₁₃H₁₃BrN₄S
Molecular Weight: 337.23800
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-08-02 07:25:58
Modify Date: 2024-01-10 11:15:06
Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.IC50 value: 7 nMTarget: HIV-1Trovirdine is currently in phase I clinical trials for potential use in thetreatment of AIDS.

Name	Trovirdine
Synonyms	Thiourea,N-(5-bromo-2-pyridinyl)-N'-[2-(2-pyridinyl)ethyl] Hi-142 LY-300046

Description	Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.IC50 value: 7 nMTarget: HIV-1Trovirdine is currently in phase I clinical trials for potential use in thetreatment of AIDS.
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
References	[1]. Zhang, H. et al. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethylthiazolyl thiourea derivatives trovirdine and MSC-127. [2]. Cantrell, A.S. et al. Phenethylthiazolylthiourea (PETT) compounds as a newclass of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.